Large Eddy Simulations on Film Cooling Flow Behaviors with Upstream Turbulent Boundary Layer Generated by Circular Cylinder

Large eddy simulations on film cooling hole array on a flat plate was carried out to investigate upstream turbulence effect.Circular cylinders were configured to create a turbulent boundary layer and its diameter has been adjusted to generate 13% upstream turbulence intensity in the main flow.Due to the small pitch to diameter configuration of the

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The risk of amenorrhea is related to chemotherapy-induced leucopenia in breast cancer patients receiving epirubicin and taxane based chemotherapy.

BACKGROUND: Chemotherapy-induced amenorrhea (CIA) is common in young breast cancer patients.The incidence of CIA associated with regimens involving epirubicin and taxane was not well known.Furthermore, previous studies suggested leucopenia and amenorrhea may reflect inter-individual variations in pharmacokinetics.The purpose read more of this study

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A strategy for early detection of response to chemotherapy drugs based on treatment-related changes in the metabolome.

We describe a biomarker-based approach to delivering chemotherapy that entails monitoring treatment changes in the circulating metabolome that reflect efficacy.In-vitro, multiple tumor cell lines were exposed to numerous chemotherapeutics.Supernatants were collected at baseline and 72 hours post treatment.MTT assays were used to quantify growth inh

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